Covalent Organic Framework-Based Nanocomposite for Synergetic Photo‑, Chemodynamic‑, and Immunotherapies

发布日期：2020/12/4 16:29:17

Cancer deaths are mainly caused by tumor metastases. However, tumor

ablation therapies can only target the primary tumor but not inhibit tumor metastasis.

Herein, a multifunctional covalent organic framework (COF)-based nanocomposite is

designed for synergetic photo-, chemodynamic- and immunotherapies. Specififically, the

synthesized COF possesses the ability to produce singlet oxygen under the 650 nm laser

irradiation. After being metallized with FeCl3, p-phenylenediamine is polymerized on

the surface of COF with Fe3+ as the oxidant. The obtained poly(p-phenylenediamine)

can be used for photothermal therapy. Meanwhile, the overexpressed H2O2 in the

tumor would be further catalyzed and decomposed into hydroxyl radicals (• OH) by the

Fe3+/Fe2+ redox couple via Fenton reaction. Intriguingly, the increase of temperature

caused by photothermal therapy can accelerate the production of • OH. Moreover, the

tumor-associated antigen induced a robust antitumor immune response and effffectively

inhibited tumor metastasis in the presence of anti-PD-L1 checkpoint blockade. Such a

COF-based multifunctional nanoplatform provides an effiffifficacious treatment strategy for

both the primary tumor and tumor metastasis.